The studied quartzites, part of the metamorphic assemblage of the Anguran Pb-Zn deposit in the Takab-Mahneshan metallogenic belt, northwestern Iran, were investigated to determine their petrographic characteristics, geochemistry, provenance, and statistical/metallogenic controls. Petrographic studies indicate that these rocks exhibit granoblastic, polygonal, and bulging textures, with quartz comprising over 85% of their volume. The presence of siliceous and carbonate veins, chloritization of micas, and sulfide mineralization reflect the influence of metamorphic processes and late-stage fluids. Geochemical analyses reveal low concentrations of HFSEs and ∑REE،, along with high silica purity, indicating the dominance of evolved felsic crustal sources in the sedimentary basin. These sequences were initially subjected to regional metamorphism and recrystallization, and subsequently affected by hydrothermal and metasomatic fluid flow during post-metamorphic stages. High coefficients of variation and positive skewness in LILEs and heavy metals (Pb-Zn), combined with the Pearson correlation matrix, confirm the mobilization and redistribution of these elements driven by hydrothermal fluid migration. Furthermore, the geochemical behavior of sulfur and its lack of correlation with silicate phases and base metals such as Pb and Zn indicate the independent injection of sulfide phases and the formation of iron sulfide minerals such as pyrite during hydrothermal pulses; thus, the quartzites acted as reactive host rocks and fluid conduits.